Endocrine Abstracts

Introduction: Generalized lipodystrophies are rare disorders characterized by almost total loss of adipose tissue, and they are often accompanied by metabolic complications such as severe insulin resistance, diabetes mellitus, hypertriglyceridemia, and fatty liver.Case report: We diagnosed a 17-year-old woman whose subcutaneous adipose tissue began to decrease in her late elementary school days with the acquired and generalized types of idiopathic lipoat...

Introduction: Pituitary metastases occur in 1% to 4% of cancer patients in autopsy studies. The most frequent primary tumors are breast and lung tumors. Renal cell carcinoma (RCC) is a rare cause of pituitary metastases, with only 25 previously reported cases.Case report: A 77-year-old-man was admitted to our hospital because of acute progression of chronic renal failure presenting with appetite and weight loss in August 2014. He underwent hemodialysis. ...

Introduction: Isolated adrenocorticotropic hormone (ACTH) deficiency (IAD) is a rare disease, which is characterized by secondary adrenal insufficiency with low cortisol production, and normal secretion of pituitary hormones other than ACTH. Although it is known that QT prolongation is sometimes observed in patients with IAD, reports on IAD in which the QT interval was sufficiently prolonged to cause Torsades de Pointes (TdP) are rare. We described the case of a patient with I...

Introduction: Lymphocytic hypophysitis (LH) is a heterogeneous inflammatory condition in the pituitary gland, which may cause hormonal deficiency. However, some patients with LH initially present with headache.Case: A 63-year-old woman complained of a severe headache for 1 month. Examination of cerebrospinal fluid (CSF) showed increased lymphocyte counts, indicating meningitis. Contrast-enhanced magnetic resonance imaging (MRI) revealed an expanding sell...

Introduction: Erdheim-Chester disease (ECD) is a rare and aggressive form of non-Langerhans cell histiocytosis (n-LCH). Its etiology is unknown, but recently, BRAFV600E (a proto-oncogene) has been found in more than 50% of cases. This may play a part in chronic uncontrolled inflammation, which is an important aspect of disease pathogenesis.Case report: A 42-year-old woman complained of generalized weakness, polyuria, and secondary amenorrhea. Biochemistr...

Introduction: Adrenal adenoma is one of the extraintestinal lesions associated with familial adenomatous polyposis (FAP). Only four cases of Cushing’s syndrome due to adrenal adenoma complicated by FAP, including ours, have been reported to date.Case report: A 37-year-old woman presented with pretibial edema and hirsutism. She was diagnosed with FAP at 8 years old. She had undergone resection of craniopharyngioma at 10 years old and repeated removal...